Anti-Catenin; delta-1 (CTNND1) (pTyr96) Monoclonal Antibody(Clone: 25a)
Produktgrößen
20 µg
£397,00
36-2142-20UG
100 µg
£716,00
36-2142-100UG
Über dieses Produkt
- SKU:
- 36-2142
- Zusätzliche Namen:
- Cadherin-associated Src substrate (CAS); Catenin (cadherin associated protein) delta 1; Catenin delta-1; CTNND1; p120 catenin; P120 CTN; p120(cas); p120(ctn); P120CAS; P120CTN
- translate.label.attr.clone:
- 25a
- Klonalität:
- Monoclonal
- Weitere Details:
- The membrane associated protein pp120 Src substrate (p120 Catenin; p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell; p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin; p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas; sµggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96; Y112; Y228; Y280; Y257; Y291; Y296; and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus; p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules; such as cadherins and cell signaling molecules; such as PTP1C.
- Host:
- Mouse
- Immunogen:
- Mouse p120 Catenin (pY96)
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg