Anti-Catenin; beta (p120) Monoclonal Antibody(Clone: CTNNB1/2098)
Produktgrößen
20 µg
£397,00
36-2130-20UG
100 µg
£716,00
36-2130-100UG
Über dieses Produkt
- SKU:
- 36-2130
- Zusätzliche Namen:
- Cadherin associated protein; beta 1 88kDa; Catenin beta-1; CATNB; CHBCAT; CTNNB1
- translate.label.attr.clone:
- CTNNB1/2098
- Klonalität:
- Monoclonal
- Weitere Details:
- Beta-catenin associates with the cytoplasmic portion of E-cadherin; which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues; beta-catenin is localized to the membrane of epithelial cells; consistent with its role in the cell adhesion complex. In breast ductal neoplasia; beta-catenin is usually localized in cellular membranes. However; in lobular neoplasia; a marked redistribution of beta-catenin throµghout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms; including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally; some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining; mimicking the staining pattern observed with lobular breast carcinomas.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human beta-Catenin (CTNNB1) protein
- Isotyp:
- Mouse IgG2b; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
