Anti-CD195 (CC-Chemokine Receptor 5) Monoclonal Antibody (Clone: 12D1)
Produktgrößen
20 µg
£397,00
36-2102-20UG
100 µg
£716,00
36-2102-100UG
Über dieses Produkt
- SKU:
- 36-2102
- Zusätzliche Namen:
- CC Chemokine Receptor Type 5; CC-CKR-5; CCCKR5; CCR5; Chemokine CC motif receptor 5; Chemokine receptor CCR5; CHEMR13; CKR5; CMKBR5; HIV-1 fusion coreceptor; IDDM22; MIP-1 alpha receptor
- translate.label.attr.clone:
- 12D1
- Klonalität:
- Monoclonal
- Weitere Details:
- Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family; and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells; macrophages; NK cells; and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor; CCR5 plays a critical role in HIV entry into the target cells. Moreover; the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha; MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection; making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases; ranging from infectious and inflammatory diseases to cancer.
- Host:
- Mouse
- Immunogen:
- Human native CCR5 protein
- Isotyp:
- Mouse IgG2a; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
