Anti-Fas (TNFRSF6) associated factor 1 Monoclonal Antibody (Clone: CPTC-FAF1-2)
Produktgrößen
20 µg
£397,00
36-2070-20UG
100 µg
£716,00
36-2070-100UG
Über dieses Produkt
- SKU:
- 36-2070
- Zusätzliche Namen:
- CGI-03; FAS-associated factor 1; HFAF1s; UBX domain-containing protein 12; UBX domain-containing protein 3A
- translate.label.attr.clone:
- CPTC-FAF1-2
- Klonalität:
- Monoclonal
- Weitere Details:
- In contrast to growth factors which promote cell proliferation; FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor superfamily. TRADD; FADD and RIP are FAS/TNF-alphaI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-alphaI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-alphaI via their DDH regions; while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1; for FAS-associated protein factor-1; binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells; FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD; FADD and RIP; FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length FAF1 protein
- Isotyp:
- Mouse IgG2b; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
