Anti-MerTK (Innate Immune Checkpoint) Monoclonal Antibody (Clone: MERTK/3015)
Produktgrößen
20 µg
£397,00
36-2036-20UG
100 µg
£716,00
36-2036-100UG
Über dieses Produkt
- SKU:
- 36-2036
- Zusätzliche Namen:
- cEyk; MER receptor tyrosine kinase; MERK; MERPEN; nmf12; Nyk; Proto-oncogene c-Mer; RP38; STK kinase
- translate.label.attr.clone:
- MERTK/3015
- Klonalität:
- Monoclonal
- Weitere Details:
- MerTK; also called c-Mer; is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain; two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation; platelet aggregation; clot stability and the efficient removal of apoptotic cells. Specifically; MerTK acts as a signaling molecule; triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated; the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result; leading to degeneration of retinal photoreceptor cells.
- Host:
- Mouse
- Immunogen:
- Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary)
- Isotyp:
- Mouse IgG2a; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
