Monoclonal Antibody to CD74 (B-Cell Marker)(Clone : BU45)
Produktgrößen
100 µg
£716,00
36-1974-100UG
Über dieses Produkt
- SKU:
- 36-1974
- translate.label.attr.clone:
- BU45
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes proteins of 33; 35 and 41kDa; which are identified as various isoforms of CD74. Its epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 molecule plays a critical role in the presentation of peptides; by the MHC class II antigens; to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells; a subset of activated T cells; monocytes; and dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells; such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage); macrophages; and monocytes; and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas; but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- B lymphoblastoid cell line HFB1
- Isotyp:
- Mouse IgG1; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php