Monoclonal Antibody to Cyclin B1 (G2- & M-phase Cyclin)(Clone : CCNB1/1098)
Produktgrößen
100 µg
£716,00
36-1834-100UG
Über dieses Produkt
- SKU:
- 36-1834
- Zusätzliche Namen:
- CCNB1||CCNB
- translate.label.attr.clone:
- CCNB1/1098
- Klonalität:
- Monoclonal
- Weitere Details:
- It recognizes a protein of 55-62kDa; identified as cyclin B1. In mammals; cyclin B associates with inactive p34cdc2; which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis; when Cdc25; a specific protein phosphatase; dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So; cyclin B-p34cdc2 plays a critical role in G2 to M transition.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length CCNB1 protein
- Isotyp:
- Mouse IgG1; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
