Monoclonal Antibody to SUMO-2(Clone : SUMO2/1199)
Produktgrößen
100 µg
£716,00
36-1688-100UG
Über dieses Produkt
- SKU:
- 36-1688
- Zusätzliche Namen:
- SUMO3||SMT3A||SMT3H1
- translate.label.attr.clone:
- SUMO2/1199
- Klonalität:
- Monoclonal
- Weitere Details:
- The small ubiquitin-related modifier (SUMO) proteins; which include SUMO-1; 2 and 3; belong to the ubiquitin-like protein family. Like ubiquitin; the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also; both utilize the E1; E2 and E3 cascade enzymes for conjugation. However; SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation; whereas sumoylation targets proteins to a variety of cellular processing; including nuclear transport; transcriptional regulation; apoptosis and protein stability. The unconjugated SUMO-1; 2 and 3 proteins localize to the nuclear membrane; nuclear bodies and cytoplasm; respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins; which include MDM2; p53; PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1; they can form polymeric chains. In addition; SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer s disease.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant human SUMO2 protein
- Isotyp:
- Mouse IgG1; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
