Monoclonal Antibody to Cytochrome C (Mitochondrial Marker)(Clone : SPM389)
Produktgrößen
100 µg
£716,00
36-1562-100UG
Über dieses Produkt
- SKU:
- 36-1562
- Zusätzliche Namen:
- CYCS||CYC
- translate.label.attr.clone:
- SPM389
- Klonalität:
- Monoclonal
- Weitere Details:
- It recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C; a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells; this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis; cytochrome c is trans-located from the mitochondrial membrane to the cytosol; where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c; thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade; whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner; leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Synthetic peptides corresponding to amino acid 1-80; 81-104 and 66-104 of pigeon cytochrome c
- Isotyp:
- Mouse IgG2b; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
