Monoclonal Antibody to Nuclear Mitotic Apparatus Protein (NuMA)(Clone : A73-B/D12)
Produktgrößen
100 µg
£716,00
36-1521-100UG
Über dieses Produkt
- SKU:
- 36-1521
- Zusätzliche Namen:
- NUMA1||NMP22||NUMA
- translate.label.attr.clone:
- A73-B/D12
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes a phosphorylated protein of 228kDa; identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis; it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase; the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor; alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Colon carcinoma 174T cells
- Isotyp:
- Mouse IgM; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg