Monoclonal Antibody to MUC1 / EMA / CD227 (Epithelial Marker)(Clone : HMPV)
Produktgrößen
100 µg
£716,00
36-1443-100UG
Über dieses Produkt
- SKU:
- 36-1443
- Zusätzliche Namen:
- MUC1||PUM
- translate.label.attr.clone:
- HMPV
- Klonalität:
- Monoclonal
- Weitere Details:
- This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein; which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content; O-linked oligosaccharides; high molecular weight (>200kDa) and an amino acid composition rich in serine; threonine; proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Human breast cancer cell line ZR-75 cells
- Isotyp:
- Mouse IgG1; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg