Monoclonal Antibody to Microphthalmia Transcription Factor (MITF)(Clone : D5)
Produktgrößen
100 µg
£716,00
36-1433-100UG
Über dieses Produkt
- SKU:
- 36-1433
- Zusätzliche Namen:
- MITF||BHLHE32
- translate.label.attr.clone:
- D5
- Klonalität:
- Monoclonal
- Weitere Details:
- MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium; and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation; resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition; Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist; including MITF-A; MITF-B; MITF-C; MITF-H; and MITF-M; which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. Anti-MITF; D5; recognizes a nuclear protein; which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes; benign nevi and dysplastic nevi.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- NH2 terminus fragment of human Mi protein
- Isotyp:
- Mouse IgG1; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg