Monoclonal Antibody to CD54 / ICAM-1(Clone : W-CAM-1; same as Wehi-CAM-1 or 1H4)
Produktgrößen
100 µg
£716,00
36-1251-100UG
Über dieses Produkt
- SKU:
- 36-1251
- Zusätzliche Namen:
- ICAM1
- translate.label.attr.clone:
- W-CAM-1; same as Wehi-CAM-1 or 1H4
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes an 85-115kDa protein (variation with cell type); identified as intercellular adhesion molecule (ICAM-1) (Workshop IV). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family; present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts; EC; macrophages; and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule; LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. W-CAM-1 MAb blocks aggregation of cell lines mediated by the ICAM-1 and blocks homotypic binding of purified populations of activated T- and B-lymphocytes and also aggregation of mixed T- and B-cell blasts. It inhibits T-cell adhesion to normal human endothelial cells. Activation induced by cell-cell contact (mixed lymphocyte reaction; T-cell mediated B-cell activation) is significantly inhibited. This MAb blocks elements of both effector arms of immune system (cytotoxic cell function and Ig production).
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Raji Burkitt lymphoma cells
- Isotyp:
- Mouse IgG2b; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg