Monoclonal Antibody to CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker)(Clone : SPM615)
Produktgrößen
100 µg
£716,00
36-1066-100UG
Über dieses Produkt
- SKU:
- 36-1066
- Zusätzliche Namen:
- CPS1
- translate.label.attr.clone:
- SPM615
- Klonalität:
- Monoclonal
- Weitere Details:
- This MAb recognizes a protein of 165kDa; identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle; which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach; but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly; strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally; CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant human CPS1 protein
- Isotyp:
- Mouse IgG1; kappa
- Aufreinigung:
- Affinity Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg