Polyclonal Antibody to GFI1b
Produktgrößen
50 µl
£511,00
35-1832-50UL
100 µl
£581,00
35-1832-100UL
Über dieses Produkt
- SKU:
- 35-1832
- Zusätzliche Namen:
- Gfi-1b
- Klonalität:
- Polyclonal
- Weitere Details:
- Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus; may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription; such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription; both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter; auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. Osawa M.; Yamaguchi T.; Nakamura Y. Iwama A.Blood 100:2769-2777(2002) Huang D.-Y.; Kuo Y.-Y.; Chang Z.-F. Nucleic Acids Res. 33:5331-5342(2005) Vassen L.; Fiolka K.; Moeroey T. EMBO J. 25:2409-2419(2006)
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.322~326(H-R-E-S-Q) derived from Human GFI1b.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg