Polyclonal Antibody to LIN28B
Produktgrößen
50 µl
£511,00
35-1795-50UL
100 µl
£581,00
35-1795-100UL
Über dieses Produkt
- SKU:
- 35-1795
- Zusätzliche Namen:
- CSDD2|| FLJ16517
- Klonalität:
- Polyclonal
- Weitere Details:
- Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7); a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase; leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop; leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1; when overexpressed; stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma.""
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.242~246( P-S-V-Q-K) derived from Human LIN28B
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg