Polyclonal Antibody to Integrin beta1 (CD29)
Produktgrößen
50 µl
£511,00
35-1784-50UL
100 µl
£581,00
35-1784-100UL
Über dieses Produkt
- SKU:
- 35-1784
- Zusätzliche Namen:
- FNRB|| MDF2|| VLAB|| MSK12|| ITGB1
- Klonalität:
- Polyclonal
- Weitere Details:
- Integrins a-1/beta-1; a-2/beta-1; a-10/beta-1 and a-11/beta-1 are receptors for collagen. Integrins a-1/beta-1 and a-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins a-2/beta-1; a-3/beta-1; a-4/beta-1; a-5/beta-1; a-8/beta-1; a-10/beta-1; a-11/beta-1 and a-V/beta-1 are receptors for fibronectin. a-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin a-5/beta-1 is a receptor for fibrinogen. Integrin a-1/beta-1; a-2/beta-1; a-6/beta-1 and a-7/beta-1 are receptors for lamimin. Integrin a-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin a-9/beta-1 is a receptor for VCAM1; cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin a-3/beta-1 is a receptor for epiligrin; thrombospondin and CSPG4. a-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin a-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection; the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with a-7/beta-1 integrin; regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1; serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase; required for the successful completion of cytokinesis
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.790~794 (V-V-N-P-K) derived from Human Integrin b1 (CD29).
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg