Polyclonal Antibody to synaptophysin 2
Produktgrößen
50 µl
£511,00
35-1694-50UL
100 µl
£581,00
35-1694-100UL
Über dieses Produkt
- SKU:
- 35-1694
- Zusätzliche Namen:
- Synpr
- Klonalität:
- Polyclonal
- Weitere Details:
- Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms; and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP; which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles; a critical component of the fusion complex (4). Wiedenmann; B. et al. (1986) Proc Natl Acad Sci USA 83; 3500-4. Valtorta; F. et al. (2004) Bioessays 26; 445-53. Arthur; C.P. and Stowell; M.H. (2007) Structure 15; 707-14. Bonanomi; D. et al. (2007) Biochem J 404; 525-34.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg