Polyclonal Antibody to CDK4
Produktgrößen
50 µl
£511,00
35-1687-50UL
100 µl
£581,00
35-1687-100UL
Über dieses Produkt
- SKU:
- 35-1687
- Zusätzliche Namen:
- PSK-J3|| CMM3|| CMM3
- Klonalität:
- Polyclonal
- Weitere Details:
- Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4); by the abundance of their cyclin partners; and by association with CDK inhibitors of the Cip/Kip or INK family of proteins . The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27; which affects progression through the restriction point and pRb-dependent entry into S-phase . The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation; allowing the release of E2F transcription factors that activate G1/S-phase gene expression . In HeLa cells; upon UV irradiation; upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay; implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle . Hirai; H. et al. (1995) Mol. Cell. Biol. 15; 2672-2681. Sherr; C.J. (1996) Science 274; 1672-1677. Lukas; J. et al. (1996) Mol. Cell. Biol. 16; 6917-6925. Gabrielli; B.G. et al. (1999) J Biol Chem 274; 13961-9.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.295~299(L-H-K-D-E)derived from Human CDK4.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
