Polyclonal Antibody to STAT6 (Ab-641)
Produktgrößen
50 µl
£511,00
35-1405-50UL
100 µl
£581,00
35-1405-100UL
Über dieses Produkt
- SKU:
- 35-1405
- Zusätzliche Namen:
- IL-4 Stat
- Klonalität:
- Polyclonal
- Weitere Details:
- STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors; STAT family members are phosphorylated by the receptor-associated kinases; and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. By screening an embryonic lung fibroblast cDNA library with a wildtype STAT6 probe; 2 variant cDNAs were identified; which were termed STAT6B and STAT6C; encoding an N-terminal 110-amino acid truncation and a 27-amino acid deletion in the SH2 domain; respectively. All the three variants are ubiquitously expressed with STAT6B expression greatest in spleen and STAT6C expression greatest in lung. STAT6B resembles an attenuated STAT6; but that STAT6C inhibits IL-4-mediated mitogenesis and cell surface antigen expression; and is not tyrosine phosphorylated Nelms K; et al. (1999) Annu Rev Immunol. 17:701-738. Malabarba M G; et al. (1996) Biochem. J. 319:865-872. Hou J; et al. (1994) Science. 265:1701-1706. Quelle F W; et al. (1995) Mol Cell Biol. 15: 3336-3343. Takeda K; et al. (1996) Nature. 380: 627-630.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.639~643 (R-G-Y-V-P) derived from Human STAT6.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
