Polyclonal Antibody to STAT1 (Ab-701)
Produktgrößen
50 µl
£511,00
35-1399-50UL
100 µl
£581,00
35-1399-100UL
Über dieses Produkt
- SKU:
- 35-1399
- Zusätzliche Namen:
- CANDF7||ISGF-3||STAT91
- Klonalität:
- Polyclonal
- Weitere Details:
- Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors; Jak kinases (TYK2 and JAK1) are activated; leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize; associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor; that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes; which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma); STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF); migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes; inducing a cellular antiviral state. Heim M H; (1999) J Recept Signal Transduct Res. 19: 75-120. Durbin J E; et al. (1996) Cell. 84: 443-450. Meraz M A; et al. (1996) Cell. 84: 431-442. Wakao H; et al. (1994) EMBO J. 13: 2182-2191. Demoulin J; B. et al. (1999) J Biol Chem. 274: 25855-258 Ihle J N; et al. (1994) Trends Biochem Sci. 19: 222-227.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa. 699~703 (T-G-Y-I-K) derived from Human STAT1.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
