beta-catenin (Phospho-Ser715) Antibody
Produktgrößen
50 µl
£511,00
35-1358-50UL
100 µl
£581,00
35-1358-100UL
Über dieses Produkt
- SKU:
- 35-1358
- Zusätzliche Namen:
- Catenin beta-1; CTNB1; CTNNB; CTNNB1
- Klonalität:
- Polyclonal
- Weitere Details:
- Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt; forms a complex with AXIN1; AXIN2; APC; CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand; CTNNB1 is not ubiquitinated and accumulates in the nucleus; where it acts as a coactivator for transcription factors of the TCF/LEF family; leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML
- Immunogen:
- Peptide sequence around phosphorylation site of serine 715 (D-P-S(p)-Y-R) derived from Human beta-catenin.
- Aufreinigung:
- Affinity-chromatography
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C; For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies
- Datenblatt des Herstellers:1.jpg
