Polyclonal Antibody to HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220)
Produktgrößen
50 µl
£511,00
35-1312-50UL
100 µl
£581,00
35-1312-100UL
Über dieses Produkt
- SKU:
- 35-1312
- Zusätzliche Namen:
- HD4/HD5/HD9
- Klonalität:
- Polyclonal
- Weitere Details:
- Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins; resulting in transcriptional repression. In general;they do not act autonomously but as components of large multiprotein complexes; such as pRb-E2F and mSin3A; that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1; 2 and 4; which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest; differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents. Cress; W.D. and Seto; E. (2000) J Cell Physiol 184; 1-16. Vigushin; D.M. and Coombes; R.C. (2004) Curr. Cancer Drug Targets 4; 205-218. Marmorstein; R. (2001) Cell Mol Life Sci 58; 693-703. Thiagalingam; S. et al. (2003) Ann. N.Y. Acad. Sci. 983; 84-100.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 246/259/220 (T-A-S(p)-EP) derived from Human HDAC4/HDAC5/HDAC9.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
