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Antikörper

Polyclonal Antibody to AKT1/AKT2/AKT3 (phospho-Tyr315/316/312)

Produktgrößen
50 µl
£511,00
35-1301-50UL
100 µl
£581,00
35-1301-100UL
Über dieses Produkt
SKU:
35-1301
Zusätzliche Namen:
RAC-PK-alpha|| Protein kinase B
Klonalität:
Polyclonal
Weitere Details:
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF); epidermal growth factor (EGF); insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462'; thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. IGF-1 leads to the activation of AKT3; which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent. Nelms K; et al. (1999) Annu Rev Immunol. 17:701-738. Malabarba M G; et al. (1996) Biochem. J. 319:865-872. Hou J; et al. (1994) Science. 265:1701-1706. Quelle F W; et al. (1995) Mol Cell Biol. 15: 3336-3343.
Format:
Purified
Host:
Rabbit
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 315/316/312 (P-E-Y(p)-L-A) derived from Human AKT1/AKT2/AKT3.
Isotyp:
Rabbit IgG
Reaktivitäten:
Human, Mouse, Rat
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Polyclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure 2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using AKT1/AKT2/AKT3(Phospho-Tyr315/316/312) Antibody 35-1301 (left) or the same antibody preincubated with blocking peptide(right).
Figure 3: Immunofluorescence staining of methanol-fixed Hela cells using AKT1/AKT2/AKT3(phospho-Tyr315/316/312) Antibody 35-1301 .
Figure 4: Western blot analysis of extracts from 3T3 cells; treated with EGF or calf intestinal phosphatase (CIP); using AKT1/AKT2/AKT3 (phospho-Tyr315/316/312) Antibody 35-1301 .
Figure 4: Western blot analysis of extracts from 3T3 cells; treated with EGF or calf intestinal phosphatase (CIP); using AKT1/AKT2/AKT3 (phospho-Tyr315/316/312) Antibody 35-1301 .