Polyclonal Antibody to Histone H2A.X (Phospho-Ser139)
Produktgrößen
50 µl
£511,00
35-1247-50UL
100 µl
£581,00
35-1247-100UL
Über dieses Produkt
- SKU:
- 35-1247
- Zusätzliche Namen:
- H2A.X|| H2AFX|| H2a/x|| HIST5-2AX
- Klonalität:
- Polyclonal
- Weitere Details:
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin; limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation; DNA repair; DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones; also called histone code; and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Yaneva M; et al. (2005) Nucleic Acids Res. 33(16): 5320-5330. Tsukuda T; et al.(2006) Nature. Author manuscript; available in PMC 2006 March 6.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 139 (Q-A-S(p)-Q-E) derived from Human Histone H2A.X.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
