Polyclonal Antibody to AMPK Alpha1/AMPK Alpha2(Phospho-Thr183/Thr172)
Produktgrößen
50 µl
£511,00
35-1173-50UL
100 µl
£581,00
35-1173-100UL
Über dieses Produkt
- SKU:
- 35-1173
- Zusätzliche Namen:
- AMPK|| AMPKa1|| AMPK2
- Klonalität:
- Polyclonal
- Weitere Details:
- Catalytic subunit of AMP-activated protein kinase (AMPK); an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels; AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein; carbohydrate and lipid biosynthesis; as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes; and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA; ACACB; GYS1; HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes; respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1; PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane; possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2; FOXO3; histone H2B; HDAC5; MEF2C; MLXIPL/ChREBP; EP300; HNF4A; p53/TP53; SREBF1; SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2; leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress; phosphorylates 'Ser-36' of histone H2B (H2BS36ph); leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2; RPTOR and ATG1: in response to nutrient limitation; negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation; promotes autophagy by phosphorylating and activating ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1; leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1; leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure; activated by CAMKK2; leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR; EEF2K; KLC1; NOS3 and SLC12A1.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of threonine 183(L-R-T(p)-S-C)/threonine172(L- R-T(p)-S-C) derived from Human AMPK alpha1/AMPK alpha2.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
