Polyclonal Antibody to JAK2(Phospho-Tyr221)
Produktgrößen
50 µl
£511,00
35-1144-50UL
100 µl
£581,00
35-1144-100UL
Über dieses Produkt
- SKU:
- 35-1144
- Zusätzliche Namen:
- JTK10|| THCYT3
- Klonalität:
- Polyclonal
- Weitere Details:
- Non-receptor tyrosine kinase involved in various processes such as cell growth; development; differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm; plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR); prolactin (PRLR); leptin (LEPR); erythropoietin (EPOR); thrombopoietin (THPO); or type II receptors including IFN-alpha; IFN-beta; IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors; phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor; creating docking sites for STATs proteins. Subsequently; phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example; cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation; activation; and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then; STAT5 (STAT5A or STAT5B) is recruited; phosphorylated and activated by JAK2. Once activated; dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition; JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus; plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph); a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin. Dawson M.A.; Bannister A.J.; Gottgens B.; Foster S.D.; Bartke T.; Green A.R.; Kouzarides T.Nature 461:819-822(2009)
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of tyrosine 221(Q-D-Y(p)-H-I)derived from Human JAK2.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg