Polyclonal Antibody to Chk2 (Phospho-Ser516)
Produktgrößen
50 µl
£511,00
35-1141-50UL
100 µl
£581,00
35-1141-100UL
Über dieses Produkt
- SKU:
- 35-1141
- Zusätzliche Namen:
- CHEK2|| Cds1
- Klonalität:
- Polyclonal
- Weitere Details:
- In response to DNA damage and replication blocks; cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by Chk2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated; the encoded protein is known to inhibit CDC25C phosphatase; preventing entry into mitosis; and has been shown to stabilize the tumor suppressor protein p53; leading to cell cycle arrest in G1. In addition; this protein interacts with and phosphorylates BRCA1; allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome; a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also; mutations in this gene are thought to confer a predisposition to sarcomas; breast cancer; and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. Wu X; Chen J et al.(2003)J Biol Chem; 278(38): 36163-8 Schwarz JK; et al.(2003)Mol Cancer Res; 1(8): 598-609 Lou Z; et al.(2003) Nature; 421(6926): 957-61
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 516 (Q-P-S(p)-T-S) derived from Human Chk2.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg