Polyclonal Antibody to IKK Alpha (Phospho-Thr23)
Produktgrößen
50 µl
£511,00
35-1125-50UL
100 µl
£581,00
35-1125-100UL
Über dieses Produkt
- SKU:
- 35-1125
- Zusätzliche Namen:
- I kappa-B kinase alpha|| I-kappa-B kinase 1|| IKK-A|| IKK-alpha|| IKK1
- Klonalität:
- Polyclonal
- Weitere Details:
- Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation; the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NF-KB2/p100 associated with RelB; inducing its proteolytic processing to NF-KB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines. Yuan ZQ; et al.(2002) J Biol Chem; 277(33): 29973-82. Ozes ON; et al. (1999) Nature; 401(6748): 82-5.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of threonine 23 (L-G-T(p)-G-G) derived from Human IKK a.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
