Polyclonal Antibody to ATM (Phospho-Ser1981)
Produktgrößen
50 µl
£511,00
35-1118-50UL
100 µl
£581,00
35-1118-100UL
Über dieses Produkt
- SKU:
- 35-1118
- Zusätzliche Namen:
- Ataxia telangiectasia mutated homolog|| Ataxia telangiectasia mutated|| kinase ATM
- Klonalität:
- Polyclonal
- Weitere Details:
- ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus; it functions as a regulator of a wide variety of downstream proteins; including tumor suppressor proteins p53 and BRCA1; checkpoint kinase CHK2; checkpoint proteins RAD17 and RAD9; and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia; an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305. Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252. Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119. Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S) derived from Human ATM.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
