Polyclonal Antibody to Androgen Receptor (Phospho-Ser650)
Produktgrößen
50 µl
£511,00
35-1117-50UL
100 µl
£581,00
35-1117-100UL
Über dieses Produkt
- SKU:
- 35-1117
- Zusätzliche Namen:
- ANDR|| DHTR|| AR
- Klonalität:
- Polyclonal
- Weitere Details:
- The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain; DNA-binding domain; and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand; the receptor dissociates from accessory proteins; translocates into the nucleus; dimerizes; and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. Brinkman; A.O. et al. (1999) J. Steroid. Biochem. Mol. Biol. 69; 307-313. Avila; D.M. et al. (2001) J. Steroid. Biochem. Mol. Biol. 76; 135-142. Montgomery; J.S. et al. (2001) J. Pathol. 195; 138-146.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 650 (T-T-S(p)-P-T) derived from Human Androgen Receptor.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
