Polyclonal Antibody to PTEN(Phospho-Ser370)
Produktgrößen
50 µl
£511,00
35-1060-50UL
100 µl
£581,00
35-1060-100UL
Über dieses Produkt
- SKU:
- 35-1060
- Zusätzliche Namen:
- BZS|| DEC|| GLM2|| MHAM|| TEP1
- Klonalität:
- Polyclonal
- Weitere Details:
- Tumor suppressor. Acts as a dual-specificity protein phosphatase; dephosphorylating tyrosine-; serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase; removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3;4;5-trisphosphate; phosphatidylinositol 3;4-diphosphate; phosphatidylinositol 3-phosphate and inositol 1;3;4;5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3;4;5)P3 > PtdIns(3;4)P2 > PtdIns3P > Ins(1;3;4;5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis; including correct neuron positioning; dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential; whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. Myers M.P.; Pass I.; Batty I.H.; Van der Kaay J.; Stolarov J.P.; Hemmings B.A.; Wigler M.H.; Downes C.P.; Tonks N.K.Proc. Natl. Acad. Sci. U.S.A. 95:13513-13518(1998) Song M.S.; Salmena L.; Carracedo A.; Egia A.; Lo-Coco F.; Teruya-Feldstein J.; Pandolfi P.P.Nature 455:813-817(2008) Scala S.; Bruni P.; Lo Muzio L.; Mignogna M.; Viglietto G.; Fusco A.Int. J. Oncol. 13:665-668(1998)
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 370(D-V-S(p)-D-N) derived from Human PTEN.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
