Polyclonal Antibody to Akt (Phospho-Thr308)
Produktgrößen
50 µl
£594,00
35-1054-50UL
100 µl
£724,00
35-1054-100UL
Über dieses Produkt
- SKU:
- 35-1054
- Zusätzliche Namen:
- C-AKT|| PKB|| PKB-alpha|| RAC|| RAC-PK-alpha
- Klonalität:
- Polyclonal
- Weitere Details:
- General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF); epidermal growth factor (EGF); insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462'; thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Tremblay F; et al. (2005)Diabetes; 54(9): 2674-84. Xu BE; et al. (2005)J Biol Chem; 280(40): 34218-23. Samuels Y; et al. (2005)Cancer Cell; 7(6): 561-73. Di Maira G; et al. (2005)Cell Death Differ; 12(6): 668-77.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of threonine 308 (M-K-T(p)-F-C) derived from Human Akt.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
