Polyclonal Antibody to Akt (Phospho-Ser473)
Produktgrößen
50 µl
£594,00
35-1053-50UL
100 µl
£724,00
35-1053-100UL
Über dieses Produkt
- SKU:
- 35-1053
- Zusätzliche Namen:
- C-AKT|| PKB|| PKB-alpha|| RAC|| RAC-PK-alpha||akt s473||akt 473||akt ser473 antibody
- Klonalität:
- Polyclonal
- Weitere Details:
- General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF); epidermal growth factor (EGF); insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462'; thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Baudhuin LM; et al. (2004) FASEB J Feb; 18(2): 341-3. Min YH; et al. (2004) Cancer Res; 64(15): 5225-31. Feng J; et al. (2004) J Biol Chem; 279(34): 35510-7.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 473 (Q-F-S(p)-Y-S) derived from Human Akt.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
