Polyclonal Antibody to NF-KB-p105/p50(Phospho-Ser337)
Produktgrößen
50 µl
£511,00
35-1016-50UL
100 µl
£581,00
35-1016-100UL
Über dieses Produkt
- SKU:
- 35-1016
- Zusätzliche Namen:
- p50|| KBF1|| NF-kB1|| NF-KB-p50|| NFkappaB
- Klonalität:
- Polyclonal
- Weitere Details:
- NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation; immunity; differentiation; cell growth; tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65; RELB; NF-KB1/p105; NF-KB1/p50; REL and NF-KB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors; respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway; I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators; subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor; but can act as a transcriptional activator when associated with BCL3. NF-KB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function; although processing of NF-KB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3'; located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8; NF-KB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NF-KB1/p105. Beg A.A.; Baldwin A.S. Jr.Oncogene 9:1487-1492(1994) Guizani-Tabbane L.; Ben-Aissa K.; Belghith M.; Sassi A.; Dellagi K.Infect. Immun. 72:2582-2589(2004) Beinke S.; Robinson M.J.; Hugunin M.; Ley S.C.Mol. Cell. Biol. 24:9658-9667(2004)
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 337(R-K-S(p)-D-L) derived from Human NF-KB-p105/p50.
- Isotyp:
- Rabbit IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg
