Recombinant Human GDNF Family Receptor alpha-1/GFRA1 (C-Fc)
Produktgrößen
50 µg
£508,00
32-9701-50UG
500 µg
£1060,00
32-9701-500UG
Über dieses Produkt
- SKU:
- 32-9701
- Zusätzliche Namen:
- GDNF Family Receptor Alpha-1; GDNF Receptor Alpha-1; GDNFR-Alpha-1; GFR-Alpha-1; RET Ligand 1; TGF-Beta-Related Neurotrophic Factor Receptor 1; GFRA1; GDNFRA; RETL1; TRNR1
- Weitere Details:
- Source : Human Cells;Glial Cell Line-Derived Neurotrophic Factor Family Receptor -Alpha-1 (GDNFR-Alpha1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor -Alpha subtype which consists of at least four members. GFR-Alpha1and GFR-Alpha2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFR-Alphas released enzymatically from the cell surface by phosphatidylinositol phospholipase C; as well as recombinantly produced soluble GFR-Alpha1; can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFR-Alpha1 shares 93% amino acid identity with mouse GFR-Alpha1.The expression of the various GFR-Alphas are differentially regulated in the central and peripheral nervous system; suggesting complementary roles for the GFR-Alphas in mediating the activities of the GDNF family of neurotrophic factors.
- Versandbedingungen:
- Ambient
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php