Recombinant Cynomolgus Colony CD3E (C-Fc)
Produktgrößen
50 µg
£722,00
32-9634-50UG
500 µg
£1959,00
32-9634-500UG
Über dieses Produkt
- SKU:
- 32-9634
- Zusätzliche Namen:
- CD3 epsilon; CD3e antigen; CD3e antigen; epsilon polypeptide (TiT3 complex); CD3e molecule; epsilon (CD3-TCR complex); CD3e; CD3-epsilon; FLJ18683; T3E; T-cell antigen receptor complex; epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chai
- Weitere Details:
- Source : Human Cells;T-cell surface glycoprotein CD3 epsilon chain; also known as CD3E; is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E; together with CD3-gamma; CD3-delta and CD3-zeta; and the T-cell receptor alpha/beta and gamma/delta heterodimers; forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains; a proline-rich sequence and an immune tyrosine activation motifs (ITAMs); and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function; and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development; and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.
- Versandbedingungen:
- Ambient
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php