Recombinant Human Tumor Necrosis Factor Receptor/TNFRSF17/BCMA/CD269 (C-6His)
Produktgrößen
50 µg
£580,00
32-9394-50UG
500 µg
£1252,00
32-9394-500UG
Über dieses Produkt
- SKU:
- 32-9394
- Zusätzliche Namen:
- Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; TNFRSF17; BCM; BCMA
- Weitere Details:
- Source : Yeast;B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain; a 23 aa transmembrane domain; and a 107 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF; it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF; members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface; BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development;function and regulation.
- Versandbedingungen:
- Ambient
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php