Recombinant Human KDR/VEGFR-2/FLK-1(C-6His)
Produktgrößen
50 µg
£847,00
32-9374-50UG
500 µg
£1959,00
32-9374-500UG
Über dieses Produkt
- SKU:
- 32-9374
- Zusätzliche Namen:
- Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1
- Weitere Details:
- Source : Human Cells;Human Vascular endothelial growth factor receptor 2(KDR; VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis; vascular development; vascular permeability; and embryonic hematopoiesis. It also plays an essential role in promoting proliferation; survival; migration and differentiation of endothelial cells; reorganization of the actin cytoskeleton. VEGFR2 is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors; whose expression is restricted to endothelial cells in vivo.The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition; VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation; and seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth; while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
- Versandbedingungen:
- Ambient
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php