Recombinant Mouse IL-4RA/sIL4Ralpha/prot(C-Fc)
Produktgrößen
50 µg
£656,00
32-9357-50UG
500 µg
£1676,00
32-9357-500UG
Über dieses Produkt
- SKU:
- 32-9357
- Zusätzliche Namen:
- Interleukin-4 receptor subunit alpha;IL-4R-alpha;CD124;IL4-BP;Soluble IL-4R-alpha
- Weitere Details:
- Source : Human Cells;Interleukin-4 receptor subunit alpha(IL-4RA); alos known as Soluble IL-4 receptor subunit alpha; belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types; IL-4RA can signal through activation of insulin receptor substrates; IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells; IL-4RA creates a type I receptor. In non-immune cells; it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases; PTPN6/SHIP1; PTPN11/SHIP2 and INPP5D/SHIP.
- Versandbedingungen:
- Ambient
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php