Recombinant Human Endothelial Cell Adhesion Molecule/PECAM-1/CD31 (C-Fc)
Produktgrößen
50 µg
£656,00
32-9296-50UG
500 µg
£1162,00
32-9296-500UG
Über dieses Produkt
- SKU:
- 32-9296
- Zusätzliche Namen:
- Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA; PECA1; CD31; PECAM1
- Weitere Details:
- Source : Human Cells;Platelet Endothelial Cell Adhesion Molecule (PECAM1; CD31); is a heavily glycosylated transmembrane protein belonging to the immunoglobulin (Ig) superfamily of cell adhesion molecules. CD31 is composed of an extracellular domain (ECD) of 574 amino acids (aa) containing six Ig-like domains; a transmembrane domain; and a 118 aa cytoplasmic domain. CD31 is highly expressed on endothelial cells and at a lower level on platelets; granulocytes; macrophages; dendritic cells; T and B cells; and natural killer (NK) cells. It is involved in cell adhesion and is required for transepithelial migration of leukocytes (TEM). CD31 acts as a homophilic receptor through its extracellular domain and is involved in downstream signaling via its cytoplasmic domain. This domain contains highly conserved ITIM motifs which; once tyrosine phosphorylated; recruit and activate the signaling molecules Src and SHP2. The resulting inhibition of TCR signaling increases the activation threshold of T cells; thus reinforcing peripheral tolerance and preventing development of autoimmunity. CD31 additionally regulates immune responses by acting as a key inhibitory receptor in dendritic cell development. CD31 is required for the transendothelial migration of leukocytes through intercellular junctions of vascular endothelial cells.
- Versandbedingungen:
- Ambient
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php