Recombinant Human Lacritin/LACRT (N-6His)
Produktgrößen
50 µg
£612,00
32-9220-50UG
500 µg
£1788,00
32-9220-500UG
Über dieses Produkt
- SKU:
- 32-9220
- Zusätzliche Namen:
- Extracellular Glycoprotein Lacritin; LACRT
- Weitere Details:
- Source : E. coli Extracellular glycoprotein lacritin (Lacritin) is a secreted protein which consists of 119 amino acids after cleavage of the N-terminal signal peptide and displays several predicted alpha helices; mostly in the C- terminal half. Lacritin is highly expressed in the lacrimal gland; localizes primarily to secretory granules and secretory fluid. Lacritin modulates lacrimal acinar cell secretion; promotes ductal cell proliferation; and stimulates signaling through tyrosine phosphorylation and release of calcium. Lacritin is thus a multifunctional prosecretory mitogen with cell survival activity. Natural or bacterial cleavage of lacritin releases a C-terminal fragment that is bactericidal. Lacritin cell targeting is dependent on the cell surface heparan sulfate proteoglycan syndecan-1 (SDC1). Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein.
- Versandbedingungen:
- Ambient
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:LACRT-WB-32-9220.jpg