Recombinant Human CEACAM5/CD66e/CEA (C-His)
Produktgrößen
50 µg
£656,00
32-9151-50UG
500 µg
£1959,00
32-9151-500UG
Über dieses Produkt
- SKU:
- 32-9151
- Zusätzliche Namen:
- Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e; CEACAM5
- Weitere Details:
- Source : Human 293 Cells;CEACAM5; also known as CEA or D66e; is a member of the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed predominantly by epithelial cells. CEACAM5 contains one Ig-like V-type domain at the N-terminus; followed by six Ig-like C2-type domain and a GPI anchor; and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in various cancers and are associated with adhesion and invasion. CEACAM5 can regulate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a commonly used tumor marker; since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been found to contribute to tumorigenicity by inhibiting cellular differentiation. Furthermore; CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.coli; and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.
- Versandbedingungen:
- Ambient
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php