Recombinant Human Anterior gradient protein 2 homolog/AGR2(C-His)
Produktgrößen
50 µg
£772,00
32-9086-50UG
500 µg
£2009,00
32-9086-500UG
Über dieses Produkt
- SKU:
- 32-9086
- Zusätzliche Namen:
- Anterior Gradient Protein 2 Homolog; AG-2; hAG-2; HPC8; Secreted Cement Gland Protein XAG-2Homolog; AGR2; AG2
- Weitere Details:
- Source : Human 293 Cells;Anterior gradient 2 protein (AGR2) is a member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells; such as small intestine goblet; prostate epithelium; enteroendocrine cells; and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion; possibly aiding protein folding. The expression of AGR2 shows a positive correlation with the expression of estrogen receptor in breast carcinoma and a negative correlation with the expression of EGF receptor. Increased levels of extracellular AGR2 (eAGR2) have been correlated with poor prognosis in cancer patients; making it a potential biomarker. Studies revealed that increased AGR2 was associated with endoplasmic reticular homeostasis; possibly allowing tumor cells to overcome hypoxic stress and meet the increased protein demand of tumorigenesis; thereby preventing unfolded protein response-mediated apoptosis
- Versandbedingungen:
- Dry Ice
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php