Recombinant Human Thrombospondin-1/THBS1 (C-10His)
Produktgrößen
10 µg
£493,00
32-9025-10UG
50 µg
£656,00
32-9025-50UG
Über dieses Produkt
- SKU:
- 32-9025
- Weitere Details:
- Source: Human Cells. MW :129.2kD. Recombinant Human Thrombospondin-1 is produced by our expression system and the target gene encoding Asn19-Pro1170 is expressed Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain; an extended central region with one vWFC domain; 3 TSP type 1domains; 2 EGF-like domains; and 8 TSP type3 domains; and a globular TSP C-terminal domain. Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules. TSP-1 counteracts the angiogenic; hypotensive; and antithrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF; blocks VEGF R2 signaling on vascular endothelial cells(EC); and destabilizes adhesive contacts between EC. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP).
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php