Recombinant Mouse Butyrophilin-like Protein 2/BTNL2 (C-6His)
Produktgrößen
10 µg
£493,00
32-8990-10UG
50 µg
£656,00
32-8990-50UG
Über dieses Produkt
- SKU:
- 32-8990
- Weitere Details:
- Source: Human Cells. MW :48.6kD. Recombinant Mouse Butyrophilin-like Protein 2 is produced by our Mammalian expression system and the target gene encoding Asp27-Ser452 is expressed with a 6His tag at the C-terminus. Butyrophilin-like 2 (BTNL2) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation. Mouse BTNL2 is type I transmembrane glycoprotein that contains an extracellular domain (ECD); a transmembrane region and a short cytoplasmic domain. The ECD features two V-type Ig-like domains; two C-type Ig-like domains; and four glycosylation sites. BTNL2 is expressed in epithelial cells of the small intestine; colonic dendritic cells; and in cells of the lymph node. BTNL2 expression is upregulated in T cells following activation; a characteristic BTNL2 shares with the homologous B7 family of costimulatory molecules. BTNL2 negatively regulates T cells by inhibiting proliferation and inflammatory cytokine secretion. It also increases the expression of FoxP3 in T cells to promote regulatory T cell development. Single nucleotide polymorphisms in BTNL2 are associated with a risk for sporadic prostate cancer; rheumatoid arthritis; sarcoidosis; ulcerative colitis; and other inflammatory diseases.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php