Recombinant Mouse Leucine-rich Repeats and IG-like Domains Protein 1/LRIG1 (C-6His)
Produktgrößen
10 µg
£478,00
32-8975-10UG
50 µg
£631,00
32-8975-50UG
Über dieses Produkt
- SKU:
- 32-8975
- Weitere Details:
- Source: Human Cells. MW :84.5kD. Recombinant Mouse Leucine-rich Repeats and Immunoglobulin-like Domains Protein 1 is produced by our Mammalian expression system and the target gene encoding Ala35-Thr794 is expressed with a 6His tag at the C-terminus. LRIG1 is a leucine-rich repeat (LRR) and Ig-like domain-containing single-pass transmembrane glycoprotein. LRIG1 shares 45-50% aa identity with its mammalian paralogs; LRIG2 and LRIG3. LIRG1 is expressed widely throughout mouse and human tissues; including the liver; brain; stomach; small intestine; skeletal muscle; cornea; and hair follicle. It has been shown to suppress tumor growth; regulate tissue homeostasis; and maintain stem cell quiescence. The LRIG1 ECD contains three C-type Ig-like domains as well as fifteen LRRs that are flanked by cysteine-rich regions. LRIG1 functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. LRIG1 expression; which is often dysregulated in human cancers; is a prognostic indicator of cancer development and relapse; Decreased LRIG1 is associated with an increase in recurrence and mortality for a variety of cancers including breast; uterine; headandneck; glioma; prostate; and squamous cell. Tissue homeostasis and stem cell dormancy is also thought to be modulated by the actions of LRIG1 on cell proliferation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php