Recombinant Human Interleukin-5 Receptor Subunit Alpha/IL-5 Ra(C-6His)
Produktgrößen
10 µg
£554,00
32-8955-10UG
50 µg
£847,00
32-8955-50UG
Über dieses Produkt
- SKU:
- 32-8955
- Weitere Details:
- Source: Human Cells. MW :36.7kD. Recombinant Human Interleukin-5 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Asp21-Glu335 is expressed with a 6His tag at the C-terminus. Interleukin-5 Receptor alpha (IL-5Ra; CD125) is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 Ra consists of a 322 aa extracellular domain (ECD) with a WSxWS motif and a four cysteine motif; a 20 aa transmembrane segment; and a 58 aa cytoplasmic domain. Within the ECD; human IL-5Ra shares 71% aa sequence identity with mouse and rat IL-5 Ra. Alternate splicing of human IL-5 Ra generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 Ra and the transmembrane common beta chain ( betac/CD131) which is shared with the receptor complexes for IL-3 and GMCSF. IL-5 Ra binds IL-5 at low affinity and then associates with preformed betac oligomers to form the signaling competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5Ra followed by eosinophilic differentiation and activation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php