Recombinant Rat Interleukin-12/IL-12 (C-6His)
Produktgrößen
10 µg
£554,00
32-8951-10UG
50 µg
£847,00
32-8951-50UG
Über dieses Produkt
- SKU:
- 32-8951
- Weitere Details:
- Source: Human Cells. MW :36.7&22.6kD. Recombinant Rat Interleukin-12 is produced by our Mammalian expression system and the target gene encoding Met23-Ser335(p40)&Arg23-Ser215(p35) is expressed with a 6His tag at the C-terminus. Interleukin 12 (IL-12) is the founding member of the IL-12 family of heterodimeric cytokines; which have important immunological functions. IL-12 is composed of two disulfide-linkedsubunits of 35 kDa and 40 kDa; respectively. The 35 kDa subunit (p35) is an a-helical protein homologous to IL-6 and GCSF.The 40 kDa subunit(p40) contains one fibronectin type III and one Ig C2-like domain; and has a high degree of structural homology to type I cytokine receptors. Whereas p35 subunit is unique to IL-12;the p40 subunit is also utilized in IL-23.Mature rat p35 is a 194 amino acids (aa) protein that is secreted as a heterodimer linked to p40. It contains three potential N-linked glycosylation sites and shares 86%; and 58% aa sequence identity with mouse and human p35; respectively. Mature rat p40 contains 313 aa and can exist in multiple forms; including monomer; homodimer; heterodimer linked to p19 (forming IL23); and heterodimer linked to p35 (forming IL-12). IL12 facilitates hematopoietic stem cell proliferation; induces NK cell proliferation; and potentiates the expansion and late activation of Th1 CD4+ T cells.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php