Recombinant Mouse T-lymphocyte Surface Antigen Ly-9/SLAMF3/CD229 (C-6His)
Produktgrößen
10 µg
£493,00
32-8949-10UG
50 µg
£656,00
32-8949-50UG
Über dieses Produkt
- SKU:
- 32-8949
- Weitere Details:
- Source: Human Cells. MW :47kD. Recombinant Mouse T-lymphocyte surface antigen Ly-9 is produced by our Mammalian expression system and the target gene encoding Lys48-Phe454 is expressed with a 6His tag at the C-terminus. CD229(SLAMF3) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature mouse CD229 consists of a 406 aa extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains; a 21 aa transmembrane segment; and a 180 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs ITSMs. Within the first two Ig-like domains that are common to all SLAM proteins; mouse CD229 shares 22%-36% aa sequence identity with mouse 2B4; BLAME; CD2F10;CD84; CRACC; NTBA; and SLAM. CD229 is expressed on T; B; and NK cells; thymocytes and monocytes. Homophilic binding between CD229 molecules is mediated by the N-terminal Ig-like domain. Human and mouse CD229 exhibit crossspecies binding. Antigen stimulation of lymphocytes induces CD229 clustering to sites of T cell-B cell contact. Antibody ligation of CD229 can inhibit T cell activation; but CD229 knockout mice show impaired T cell immune responses; suggesting a potential role for CD229 in T cell activation or costimulation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php